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Migraine cause ‘identified’ as genetic defect

Migraine Headache Causes No Comments »

According to the BBC…

Scientists have identified a genetic defect linked to migraine which could provide a target for new treatments.

A flawed gene found in a family of migraine sufferers could help trigger the severe headaches, a study in Nature Medicine suggests.

Dr Zameel Cader of the University of Oxford said the discovery was a step forward in understanding why one in five people suffers from migraines.

The World Health Organization rates it as a leading cause of disability.

A migraine is a severe, long-lasting headache usually felt as a throbbing pain at the front or on one side of the head.

Some can have a warning visual disturbance, called an aura, before the start of the headache, and many people also have symptoms such as nausea and sensitivity to light during the headache itself.

Until now, the genes directly responsible for migraine have been unknown.

In this study, scientists including some from the Medical Research Council’s Functional Genomics Unit at the University of Oxford found a gene known as TRESK was directly attributable as a cause of migraine in some patients.

‘Activate’ gene
 
The study found that if the gene does not work properly, environmental factors can more easily trigger pain centres in the brain and cause a severe headache.

The international team used DNA samples from families with common migraine to identify the defective gene.

Dr Aarno Palotie, from the Wellcome Trust Sanger Institute, said the breakthrough could eventually lead to new drugs which could switch off the pain of migraines.

“It opens new avenues for planning new research which possibly could then lead to new treatments… but of course it’s a long road.”

Dr Cader, one of the MRC researchers involved in the study, said: “Previous studies have identified parts of our DNA that increase the risk in the general population, but have not found genes which can be directly responsible for common migraine.

“What we’ve found is that migraines seem to depend on how excitable our nerves are in specific parts of the brain.

“Finding the key player which controls this excitability will give us a real opportunity to find a new way to fight migraines and improve the quality of life for those suffering.”

He told the BBC’s Today programme the research showed the defective gene in migraine patients was under-active, therefore causing the headaches.

“So what we want to do is find a drug that will activate the gene,” he added.

Professor Peter Goadsby, trustee of The Migraine Trust, said: “The identification of a mutation in a gene for the potassium channel in a family with migraine with aura provides both a further important part of the puzzle in understanding the biology of migraine, and a novel direction to consider new therapies in this very disabling condition.”

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Abdominal Migraine

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Migraine – Headache From Hell

Migraine means "half cranium" in French. This malady is so named because it is a severe headache that usually affects only one side of the head. It often begins in puberty and disappears after 50. The condition runs in families and affects more women than men.

Abdominal MigraineChanges in the blood vessels of the neck are believed to cause an attack. So will high blood pressure, atherosclerosis (hardening of the arteries), an allergic reaction to certain drugs or foods, glandular abnormalities and emotional stress and anxiety.


‘Although much about headaches still isn’t understood, some researchers think migraines may be caused by functional changes in the trigeminal nerve system, a major pain pathway in your nervous system, and by imbalances in brain chemicals, including serotonin, which plays a regulatory role for pain messages going through this pathway,’ explained the Mayo Clinic.

‘During a headache, serotonin levels drop. Researchers believe this causes the trigeminal nerve to release substances called neuropeptides, which travel to your brain’s outer covering (meninges). There they cause blood vessels to become dilated and inflamed. The result is headache pain,’ it added.

Some patients experience sensory warning signs or auras prior or during an attack. These include flashes of light in the center of the field of vision or a flickering sensation in one eye. The patient may experience feelings of apprehension, irritability and restlessness before the headache begins. Others signs and symptoms are nausea, vomiting and extreme sensitivity to light and sound.

Extremes in temperature, cigarette smoke, perfume, glaring lights and hormones may trigger an attack. If there is one trait migraine sufferers share, it is their being neurotic perfectionists. To remedy this, plan your activities so you won’t be overworked and learn to relax once in a while.

‘Certain foods appear to trigger headaches in some people. Common offenders include alcohol, especially beer and red wine; aged cheeses; chocolate; fermented, pickled or marinated foods; aspartame; overuse of caffeine; monosodium glutamate – a key ingredient in some Asian foods; certain seasonings; and many canned and processed foods. Skipping meals or fasting also can trigger migraines,’ revealed the Mayo Clinic.

A migraine attack may occur daily, once a month or once a year. Untreated, it may last from four to 72 hours. While there’s no cure for migraine, medications can reduce the frequency of migraine and stop the pain.

‘Choosing a strategy to manage your migraines depends on the frequency and severity of your headaches, the degree of disability your headaches cause, and your other medical conditions. You may be a candidate for preventive therapy if you have two or more debilitating attacks a month, if you use pain-relieving medications more than twice a week, if pain-relieving medications aren’t helping, or if your migraine signs and symptoms include a prolonged aura or numbness and impaired movement on one side of your body,’ concluded the Mayo Clinic.

To help you rest during an attack, take Sedamine – the supplement that will help you sleep naturally.

By: Sharon Bell

 

Sharon Bell is an avid health and fitness enthusiast and published author. Many of her insightful articles can be found at the premier online news magazine www.HealthLinesNews.com. Visit sedamine.com/ for details on Sedamine.

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